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What medicines can ease migraine-related nausea?

Expert:   Joshua Cohen, M.D., M.P.H. , St. Luke’s-Roosevelt Hospital Center »

Sometimes it feels almost impossible to take-and keep down-- medications that relieve the headache pain. That's where the anti-nausea meds come in. Watch this to learn which ones are best!

Transcript: Nausea and vomiting are two very common migraine symptoms. Sometimes, they make it almost impossible to take—and keep down-- medications that relieve the headache pain. That’s where the anti-nausea meds come in. If a person is unable to swallow a pill or keep it in their system, many migraine medicines come in a suppository or injection form. The first anti-nausea medication I’ll discuss is called PROMETHAZINE HYDROCHLORIDE, or Phenergan. It’s taken about every four to six hours, as needed. CHLORPROMAZINE, sold under the brand name Thorazine, is often used to treat psychiatric problems such as schizophrenia or bipolar disorder. But it is sometimes prescribed to relieve migraine-related nausea and vomiting. Another medicine is PROCHLORPERAZINE, better known as Compazine. It can also be used to treat schizophrenia, but people with migraine find it is effective in quelling nausea. TRIMETHOBENZAMIDE HYDROCHLORIDE, or Tigan, is an anthistamine, but it doesn’t just treat allergies. For people with migraine, it may work by decreasing activity in the part of the brain that is related to nausea. METOCLOPRAMIDE HYDROCHLORIDE, sold under the name Reglan, is commonly used to treat nausea in people just out of surgery or undergoing chemotherapy. But doctors may prescribe it for migraine sufferers, too. DOMPERIDONE, known under the brand names Dompan or Motinorm, is another drug doctors prescribe for nausea and vomiting. It works by increasing the contractions of the stomach and bowel. More »

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